Article
Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas.
Molecular and cellular endocrinology - 5 May 2017
Yagnik Garima, Jahangiri Arman, Chen Rebecca, Wagner Jeffrey R, Aghi Manish K
Abstract excerpt
Non-functional pituitary adenomas (NFPAs) are among the commonest intracranial neoplasms. While histologically benign, NFPAs sometimes become large enough to limit therapeutic options and reduce quality of life. Investigations of the molecular etiology of NFPAs have failed to identify prevalent genetic changes and, while a role for p53 has been suggested, TP53 gene alterations have yet to be described in NFPAs....
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