Absence of mutations in the p53 tumor suppressor gene in non-invasive Cushing adenomas.

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Article

Absence of mutations in the p53 tumor suppressor gene in non-invasive Cushing adenomas.

Medicina - 1 Jan 1999

Copelli S B, Loza Coll M A, Bruno O D

Abstract excerpt

A lot of evidence supports the existence of a monoclonal origin for pituitary tumors, and several genetic alterations have already been confirmed as necessary or sufficient for unrestrained cellular growth and pituitary function. The p53 gene, a known tumor-suppressor gene (TSG), encodes a protein that exerts antiproliferative effects such as cell-growth arrest and apoptosis in response to several types of...

Topics

Adenoma
Cushing Syndrome
Electrophoresis, Polyacrylamide Gel
Exons
Genes, p53
Genetic Markers
Humans
Mutation
Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

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PMID: 10684166

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