Article
TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome.
Acta neuropathologica communications - 19 Sept 2022
Perez-Rivas Luis Gustavo, Simon Julia, Albani Adriana, Tang Sicheng, Roeber Sigrun, Assié Guillaume, Deutschbein Timo, Fassnacht Martin, Gadelha Monica R, Hermus Ad R, Stalla Günter K, Tichomirowa Maria A, Rotermund Roman, Flitsch Jörg, Buchfelder Michael, Nasi-Kordhishti Isabella, Honegger Jürgen, Thorsteinsdottir Jun, Saeger Wolfgang, Herms Jochen, Reincke Martin, Theodoropoulou Marily
Abstract excerpt
Corticotroph macroadenomas are rare but difficult to manage intracranial neoplasms. Mutations in the two Cushing's disease mutational hotspots USP8 and USP48 are less frequent in corticotroph macroadenomas and invasive tumors. There is evidence that TP53 mutations are not as rare as previously thought in these tumors. The aim of this study was to determine the prevalence of TP53 mutations in corticotroph tumors,...
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