Article
Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors.
Frontiers in endocrinology - 1 Jan 2024
Pękul Monika, Szczepaniak Magdalena, Kober Paulina, Rusetska Natalia, Mossakowska Beata J, Baluszek Szymon, Kowalik Artur, Maksymowicz Maria, Zieliński Grzegorz, Kunicki Jacek, Witek Przemysław, Bujko Mateusz
Abstract excerpt
Introduction: Corticotroph pituitary neuroendocrine tumors (PitNETs) develop from ACTH-producing cells. They commonly cause Cushing's disease (CD), however, some remain clinically silent. Recurrent USP8, USP48, BRAF and TP53 mutations occur in corticotroph PitNETs. The aim of our study was to determine frequency and relevance of these mutations in a possibly large series of corticotroph PitNETs. Methods: Study...
Topics
- Humans
- Female
- Pituitary Neoplasms
- Corticotrophs
- Proto-Oncogene Proteins B-raf
- Endopeptidases
- ACTH-Secreting Pituitary Adenoma
- Pituitary ACTH Hypersecretion
- Mutation
- Adenoma
- Deubiquitinating Enzymes
- Tumor Suppressor Protein p53