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Article

Influence of a mutation in the ATP-binding region of Ca2+/calmodulin-dependent protein kinase II on its interaction with peptide substrates.

The Biochemical journal - 1 Mar 2004

Praseeda Mullasseril, Pradeep Kurup K, Krupa Ananth, Krishna S Sri, Leena Suseela, Kumar R Rajeev, Cheriyan John, Mayadevi Madhavan, Srinivasan Narayanaswamy, Omkumar Ramakrishnapillai V

Abstract excerpt

CaMKII (Ca2+/calmodulin-dependent protein kinase II) is expressed in high concentrations in the brain and is found enriched in the postsynaptic densities. The enzyme is activated by the binding of calmodulin to the autoregulatory domain in the presence of high levels of intracellular Ca2+, which causes removal of auto-inhibition from the N-terminal catalytic domain. Knowledge of the 3D (three-dimensional)...

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PMID: 14558884
DOI: 10.1042/BJ20030741
PMCID: PMC1223949

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