Article
Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.
The Journal of biological chemistry - 5 Jun 1990
George S E, VanBerkum M F, Ono T, Cook R, Hanley R M, Putkey J A, Means A R
Abstract excerpt
To evaluate the role of domain I of calmodulin (CaM) in the activation of target enzymes, a series of CaM mutants was constructed in which domain I (49 amino acids) was substantially deleted, or was exchanged with the homologous region (58 amino acids) of cardiac troponin C (cTnC). The proteins are 1) aM, a mutant CaM in which domain I has been deleted; 2) TaM, first domain of cTnC, last three domains of CaM; 3)...
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