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Article

Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targeting.

The Journal of biological chemistry - 31 Jul 1998

Heist E K, Srinivasan M, Schulman H

Abstract excerpt

Translocation of protein kinases with broad substrate specificities between different subcellular compartments by activation of signaling pathways is an established mechanism to direct the activity of these enzymes toward particular substrates. Recently, we identified two isoforms of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II), which are targeted to the nucleus by an alternatively spliced nuclear...

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PMID: 9677407
DOI: 10.1074/jbc.273.31.19763

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