Article
Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targeting.
The Journal of biological chemistry - 31 Jul 1998
Heist E K, Srinivasan M, Schulman H
Abstract excerpt
Translocation of protein kinases with broad substrate specificities between different subcellular compartments by activation of signaling pathways is an established mechanism to direct the activity of these enzymes toward particular substrates. Recently, we identified two isoforms of Ca2+/calmodu...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- COS Cells
- Calcium
- Calcium-Calmodulin-Dependent Protein Kinase Type 1
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Calcium-Calmodulin-Dependent Protein Kinase Type 4
- Calcium-Calmodulin-Dependent Protein Kinases
- Fluorescent Antibody Technique
- Immunohistochemistry
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nuclear Localization Signals
- Phosphorylation
- Receptors, Cytoplasmic and Nuclear
- Serine