Article
Analysis of TFIIA function In vivo: evidence for a role in TATA-binding protein recruitment and gene-specific activation.
Molecular and cellular biology - 1 Dec 1999
Liu Q, Gabriel S E, Roinick K L, Ward R D, Arndt K M
Abstract excerpt
Activation of transcription can occur by the facilitated recruitment of TFIID to promoters by gene-specific activators. To investigate the role of TFIIA in TFIID recruitment in vivo, we exploited a class of yeast TATA-binding protein (TBP) mutants that is activation and DNA binding defective. We found that co-overexpression of TOA1 and TOA2, the genes that encode yeast TFIIA, overcomes the activation defects...
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