Article
DNA sequence bias during Tn5 transposition.
Journal of molecular biology - 30 Jan 2004
Ason Brandon, Reznikoff William S
Abstract excerpt
Transposition is one of the primary mechanisms causing genome instability. This phenomenon is mechanistically related to other DNA rearrangements such as V(D)J recombination and retroviral DNA integration. In the Tn5 system, only one protein, the transposase (Tnp), is required for all of the catalytic steps involved in transposon movement. The complexity involved in moving multiple DNA strands within one active...
Topics
- Base Sequence
- DNA Footprinting
- DNA Transposable Elements
- Deoxyribonuclease I
- Mutation
- Transposases
