Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2022

Das Debabrata, Seemann Jacob, Greenstein David, Schedl Tim, Arur Swathi

Abstract excerpt

The fidelity of a signaling pathway depends on its tight regulation in space and time. Extracellular signal-regulated kinase (ERK) controls wide-ranging cellular processes to promote organismal development and tissue homeostasis. ERK activation depends on a reversible dual phosphorylation on the TEY motif in its active site by ERK kinase (MEK) and dephosphorylation by DUSPs (dual specificity phosphatases). LIP-1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Germ Cells

Share to Mitogen-Activated Protein Kinase 1

Share to Oocytes

Share to Protein Tyrosine Phosphatases

Share to Synaptonemal Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 35022236
DOI: 10.1073/pnas.2113649119
PMCID: PMC8784128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline.PMID 35022236Read ↗

Multiple Functions and Dynamic Activation of MPK-1 Extracellular Signal-Regulated Kinase Signaling in<i>Caenorhabditis elegans</i>Germline DevelopmentSemantic proximity Read ↗

The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells.Semantic proximity Read ↗

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.Semantic proximity Read ↗

The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.Semantic proximity Read ↗

Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase.Semantic proximity Read ↗

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation in <em>Caenorhabditis elegans</em>Semantic proximity Read ↗

Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1.Semantic proximity Read ↗

Non-autonomous PMK-1/p38 MAPK signaling ensures homeostatic downregulation of germline stem cell proliferation in <i>C. elegans</i>Semantic proximity Read ↗

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.Semantic proximity Read ↗

A parental requirement for dual-specificity phosphatase 6 in zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.