Article
MAP kinase binds to the NH2-terminal activation domain of c-Myc.
FEBS letters - 24 Oct 1994
Gupta S, Davis R J
Abstract excerpt
The transcription factor c-Myc is a substrate for phosphorylation by MAP kinases. Here we demonstrate that MAP kinase binds to c-Myc. The NH2-terminal region (residues 1-100) is necessary and sufficient for this interaction. Binding to c-Myc is not dependent on the state of MAP kinase activation. However, the c-Myc/MAP kinase complex is disrupted by ATP. Together, these observations indicate that substrate...
Topics
- Adenosine Triphosphate
- Amino Acid Sequence
- Binding Sites
- Enzyme Activation
- Mitogen-Activated Protein Kinase 1
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Binding
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases