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Article

Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.

Oncogene - 1 Jan 1993

Davis L J, Halazonetis T D

Abstract excerpt

The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not interact with Max. Specific association of c-Myc with Max was dictated by helices 1 and 2 of the HLH motif and by the...

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PMID: 8423990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.PMID 8423990Read ↗

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