Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.

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Article

Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.

Oncogene - 1 Jan 1993

Davis L J, Halazonetis T D

Abstract excerpt

The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not i...

Topics

Amino Acid Sequence
Animals
Base Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Basic-Leucine Zipper Transcription Factors
Cell Transformation, Neoplastic
DNA
DNA-Binding Proteins
Leucine Zippers
Molecular Sequence Data
Mutation
Proto-Oncogene Proteins c-myc
Rats
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 8423990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8423990-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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