Article
Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.
Structure (London, England : 1993) - 1 Dec 2015
Helander Sara, Montecchio Meri, Pilstål Robert, Su Yulong, Kuruvilla Jacob, Elvén Malin, Ziauddin Javed M E, Anandapadamanaban Madhanagopal, Cristobal Susana, Lundström Patrik, Sears Rosalie C, Wallner Björn, Sunnerhagen Maria
Abstract excerpt
Hierarchic phosphorylation and concomitant Pin1-mediated proline isomerization of the oncoprotein c-Myc controls its cellular stability and activity. However, the molecular basis for Pin1 recognition and catalysis of c-Myc and other multisite, disordered substrates in cell regulation and disease is unclear. By nuclear magnetic resonance, surface plasmon resonance, and molecular modeling, we show that Pin1...
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