Article
The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.
The Journal of biological chemistry - 12 Dec 2003
Iavarone Carlo, Catania Annunziata, Marinissen Maria Julia, Visconti Roberta, Acunzo Mario, Tarantino Carolina, Carlomagno M Stella, Bruni Carmelo B, Gutkind J Silvio, Chiariello Mario
Abstract excerpt
Pro-inflammatory cytokines, environmental stresses, as well as receptor tyrosine kinases regulate the activity of JNK. In turn, JNK phosphorylates Jun members of the AP-1 family of transcription factors, thereby controlling processes as different as cell growth, differentiation, and apoptosis. Still, very few targets of the JNK-Jun pathway have been identified. Here we show that JNK is required for the induction...
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