Article
Transcriptional activation by the Myc oncoprotein.
Current topics in microbiology and immunology - 1 Jan 2006
Cole M D, Nikiforov M A
Abstract excerpt
The Myc transcription factor functions as a downstream effector of most mitogenic signals. Myc is synthesized rapidly in response to extracellular mitogenic signals, and blocking Myc induction abolishes or at least severely attenuates any mitogenic response. Furthermore, ectopic Myc expression can often bypass the requirement for extracellular signals for entry into S phase. Thus, the Myc transcription factor is...
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