Article

Undruggable oncoproteins cMyc and NMyc bind to mediator of transcription with superior high affinity

2024-03-15

Abstract excerpt

The overexpression of MYC genes is frequently found in many human cancers including adult and pediatric malignant brain tumors. Targeting MYC genes continues to be challenging due to their undruggable nature. The nine-amino-acid activation domain (9aaTAD) has been identified using our prediction algorithm in all four Yamanaka factors including c-Myc and showed to activate transcription as short peptides. We genera...

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Literature Corpus work: bba07905-4a64-59e8-9d1f-eeeca2b14d38
DOI: 10.1101/2024.03.15.585150

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