Article
Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction.
Carcinogenesis - 1 Oct 1994
Ashby J, Short J M, Jones N J, Lefevre P A, Provost G S, Rogers B J, Martin E A, Parry J M, Burnette K, Glickman B W
Abstract excerpt
Earlier studies have established that the rodent bladder carcinogen o-anisidine (OA) gives negative results in all of the standard rodent genetic toxicity assays. In the present study, a single oral administration of the maximum tolerated dose level (750 mg/kg) of OA to B6C3F1 mice yielded negative results in 32P-post-labelling assays of bladder and liver DNA (24 h after dosing). Likewise, 14C-ring-labelled OA...
Topics
- Aniline Compounds
- Animals
- Carbon Radioisotopes
- Carcinogens
- DNA
- DNA Adducts
- Dose-Response Relationship, Drug
- Female
- Liver
- Mice
- Mice, Transgenic