Article
Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas.
Carcinogenesis - 1 Oct 1994
Romach E, Moore J, Rummel S, Richie E
Abstract excerpt
N-methyl-N-nitrosourea (MNU) induces thymic lymphomas in AKR mice after a 2-3 month latency. This study shows that hormonal factors profoundly influence MNU-induced lymphomagenesis. Tumor development is accelerated in females compared to males, regardless of whether a single high dose or multiple...
Topics
- Animals
- Antigens, Differentiation
- Cocarcinogenesis
- Drug Administration Schedule
- Female
- Genes, ras
- Gonadal Steroid Hormones
- Injections, Intraperitoneal
- Lymphoma
- Male
- Methylnitrosourea
- Mice
- Mice, Inbred AKR
- Mutation
- Orchiectomy
- Ovariectomy
- Phenotype
- Sex Factors