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Article

Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas.

Carcinogenesis - 1 Oct 1994

Romach E, Moore J, Rummel S, Richie E

Abstract excerpt

N-methyl-N-nitrosourea (MNU) induces thymic lymphomas in AKR mice after a 2-3 month latency. This study shows that hormonal factors profoundly influence MNU-induced lymphomagenesis. Tumor development is accelerated in females compared to males, regardless of whether a single high dose or multiple low doses of MNU are administered. Testosterone is implicated in this phenomenon, since castrated mice develop...

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Source

Identifiers

PMID: 7955066
DOI: 10.1093/carcin/15.10.2275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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