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Article

Staging of T-cell receptor beta chain gene rearrangements and ras oncogene mutations in the development of murine thymic lymphomas.

Cancer research - 15 Mar 1991

Sloan S R, Pellicer A

Abstract excerpt

While it is known that the T-cell receptor beta chain gene is rearranged in fully developed murine thymic lymphomas induced by N-nitrosomethylurea and that the ras gene is activated in approximately 50% of these tumors (L. E. Diamond et al., Mol. Cell. Biol., 8: 2233-2236, 1988), it is unknown when these events occur or where the cells committed to a malignant phenotype are first located. We have studied these...

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PMID: 1847841

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Source receipt: pubmed, retrieved 7 Sept 2026.

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