Article
Staging of T-cell receptor beta chain gene rearrangements and ras oncogene mutations in the development of murine thymic lymphomas.
Cancer research - 15 Mar 1991
Sloan S R, Pellicer A
Abstract excerpt
While it is known that the T-cell receptor beta chain gene is rearranged in fully developed murine thymic lymphomas induced by N-nitrosomethylurea and that the ras gene is activated in approximately 50% of these tumors (L. E. Diamond et al., Mol. Cell. Biol., 8: 2233-2236, 1988), it is unknown when these events occur or where the cells committed to a malignant phenotype are first located. We have studied these...
Topics
- Animals
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genes, ras
- Lymphoma
- Methylnitrosourea
- Mice
- Mutation
- Neoplasm Staging
- Thymus Neoplasms
- Time Factors