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Article

Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors.

Hormones & cancer - 1 Jun 2012

Simanainen Ulla, Gao Yan Ru, Walters Kirsty A, Watson Geoff, Desai Reena, Jimenez Mark, Handelsman David J

Abstract excerpt

Hormones, notably estrogens, are pivotal in the origins of breast cancer but androgenic effects, while supported by persistence of AR expression in breast cancers, remain controversial. This study determined the role of the androgen actions via androgen receptor (AR) in experimental mammary cancer. Androgen-resistant female and male mice (ARKO) were generated using Cre/loxP technique and featured a global AR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cell Transformation, Neoplastic

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Source

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Identifiers

PMID: 22370991
DOI: 10.1007/s12672-012-0107-9
PMCID: PMC10358147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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