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Article

Flow cytometric analysis of thymic lymphosarcoma induced by N-methyl-N-nitrosourea in C57B1/6J mice.

Carcinogenesis - 1 Mar 1992

Frank A A, Collier J M, Forsyth C A, Oughton J A, Kerkvliet N I

Abstract excerpt

N-Methyl-N-nitrosourea (MNU) induces thymic lymphosarcoma in numerous mouse strains. We determined the neoplastic phenotype induced by MNU in 20 C57B1/6J mice. Eleven neoplasms were composed of cells that were CD4-CD8+, four neoplasms were composed of cells that were CD4+CD8+, two neoplasms were mixtures of CD4+CD8+ and CD4-CD8+ cells, and three neoplasms were made up of cells that expressed neither CD4 nor CD8....

Topics

Animals
Antigens, CD
Antigens, Differentiation
CD24 Antigen
CD4 Antigens
CD8 Antigens
Flow Cytometry
Lymphoma, Non-Hodgkin
Membrane Glycoproteins
Methylnitrosourea
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred AKR

Mice, Inbred C57BL

Phenotype

Thymus Neoplasms

Source

Identifiers

PMID: 1547544
DOI: 10.1093/carcin/13.3.509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1547544-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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