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Article

Transactivation of the EGR1 gene contributes to mutant p53 gain of function.

Cancer research - 15 Nov 2004

Weisz Lilach, Zalcenstein Amir, Stambolsky Perry, Cohen Yehudit, Goldfinger Naomi, Oren Moshe, Rotter Varda

Abstract excerpt

Tumor-associated mutants of the p53 tumor suppressor protein exert biological activities compatible with an oncogenic gain of function. To explore the underlying molecular mechanism, we performed microarray analysis, comparing p53-null cells to mutant p53-expressing cells. One of the genes up-regulated in the presence of mutant p53 was EGR1, a transcription factor implicated in growth control, apoptosis, and...

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Source

Identifiers

PMID: 15548700
DOI: 10.1158/0008-5472.CAN-04-1145

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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