Article
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
Cancer research - 1 Mar 1994
el-Deiry W S, Harper J W, O'Connor P M, Velculescu V E, Canman C E, Jackman J, Pietenpol J A, Burrell M, Hill D E, Wang Y
Abstract excerpt
The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to determine the relationship between the expression of WAF1/CIP1 and endogenous regulation of p53 function. WAF1/CIP1 protein...
Topics
- Alleles
- Animals
- Apoptosis
- Cell Nucleus
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- G1 Phase
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans