Article
An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization.
Biochemistry - 29 Nov 1994
Li S C, Deber C M, Shoelson S E
Abstract excerpt
Internalization of insulin and its receptor via receptor-mediated endocytosis is an important step in insulin-induced signal transduction. To investigate the structural determinants underlying the enhanced internalization rate observed for the insulin receptor transmembrane mutant Gly933-Pro934--...
Topics
- Amino Acid Sequence
- Cell Membrane
- Circular Dichroism
- Endocytosis
- Kinetics
- Macromolecular Substances
- Micelles
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Peptide Fragments
- Protein Structure, Secondary
- Receptor, Insulin
- Structure-Activity Relationship
- Temperature