Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A beta-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for alpha-adaptin association.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1999

Vleurick L, Pezet A, Kühn E R, Decuypere E, Edery M

Abstract excerpt

Intracellular trafficking of GH and its receptor, more particularly the chicken GH receptor (cGHR), was examined in COS-7 cells using biochemical and structural studies. Internalization of radioactive GH by the cGHR is reduced as compared with the rat GHR. On the contrary, activation of gene transcription through Janus kinase-2 was similar for both species. Secondary structures of the cytoplasmic domain of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Growth Hormone

Share to Janus Kinase 2

Share to Milk Proteins

Share to Precipitin Tests

Share to Receptors, Somatotropin

Share to STAT5 Transcription Factor

Source

Identifiers

PMID: 10551776
DOI: 10.1210/mend.13.11.0371

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A beta-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for alpha-adaptin association.PMID 10551776Read ↗

Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling.Semantic proximity Read ↗

Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling.Semantic proximity Read ↗

Structural determinants regulating cell surface targeting of melanocortin receptors.Semantic proximity Read ↗

Janus Kinase 2 Enhances the Stability of the Mature Growth Hormone ReceptorSemantic proximity Read ↗

Structural basis for activation of the growth hormone-releasing hormone receptor.Semantic proximity Read ↗

Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.Semantic proximity Read ↗

Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor.Semantic proximity Read ↗

The growth hormone receptor: mechanism of activation and clinical implications.Semantic proximity Read ↗

Alternative Processing of Growth Hormone Receptor Transcripts*Semantic proximity Read ↗

Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A.Semantic proximity Read ↗

Conserved Anti-Müllerian Hormone: Anti-Müllerian Hormone Type-2 Receptor Specific Interaction and Intracellular Signaling in Teleosts1Semantic proximity Read ↗

Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.