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Article

Probing the mechanism of insulin fibril formation with insulin mutants.

Biochemistry - 27 Jul 2001

Nielsen L, Frokjaer S, Brange J, Uversky V N, Fink A L

Abstract excerpt

The molecular basis of insulin fibril formation was investigated by studying the structural properties and kinetics of fibril formation of 20 different human insulin mutants at both low pH (conditions favoring monomer/dimer) and at pH 7.4 (conditions favoring tetramer/hexamer). Small-angle X-ray scattering showed insulin to be monomeric in 20% acetic acid, 0.1 M NaCl, pH 2. The secondary structure of the mutants...

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Identifiers

PMID: 11444987
DOI: 10.1021/bi0105983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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