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Cys860 in the extracellular domain of insulin receptor beta-subunit is critical for internalization and signal transduction.

Endocrinology - 1 Feb 1998

Maggi D, Andraghetti G, Carpentier J L, Cordera R

Abstract excerpt

The C860S mutation (IRC860S) in the extracellular domain of the insulin receptor beta-subunit has previously been shown to result in an inhibition of insulin receptor internalization. The present work aims at further dissecting the consequences of this mutation not only on insulin receptor internalization, but also on the signaling of the receptor. Following transfection of Chinese hamster ovary (CHO) cells with...

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PMID: 9449617
DOI: 10.1210/endo.139.2.5744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cys860 in the extracellular domain of insulin receptor beta-subunit is critical for internalization and signal transduction.PMID 9449617Read ↗

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An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor.Semantic proximity Read ↗

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