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Article

All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.

Proteins - 1 Jun 2013

Vashisth Harish, Abrams Cameron F

Abstract excerpt

Insulin regulates blood glucose levels in higher organisms by binding to and activating insulin receptor (IR), a constitutively homodimeric glycoprotein of the receptor tyrosine kinase (RTK) superfamily. Therapeutic efforts in treating diabetes have been significantly impeded by the absence of structural information on the activated form of the insulin/IR complex. Mutagenesis and photo-crosslinking experiments...

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Identifiers

PMID: 23348915
DOI: 10.1002/prot.24255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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