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Article

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.

The Journal of cell biology - 1 Aug 1992

Backer J M, Shoelson S E, Weiss M A, Hua Q X, Cheatham R B, Haring E, Cahill D C, White M F

Abstract excerpt

We have investigated the role of tyrosine residues in the insulin receptor cytoplasmic juxtamembrane region (Tyr953 and Tyr960) during endocytosis. Analysis of the secondary structure of the juxtamembrane region by the Chou-Fasman algorithms predicts that both the sequences GPLY953 and NPEY960 form tyrosine-containing beta-turns. Similarly, analysis of model peptides by 1-D and 2-D NMR show that these sequences...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cricetinae
Endocytosis
Insulin
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Phosphorylation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Insulin

Tyrosine

Source

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Identifiers

PMID: 1500426
DOI: 10.1083/jcb.118.4.831
PMCID: PMC2289561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1500426-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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