Article
Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction.
British journal of cancer - 1 Nov 1994
Cawkwell L, Lewis F A, Quirke P
Abstract excerpt
We report here the use of multiplex fluorescent polymerase chain reaction (PCR) for quantitative allele loss detection using microsatellites with 2-5 base pair repeat motifs. Allele loss of APC, DCC, p53 and RB1 in colorectal tumours has been reported previously using a variety of methods. Howeve...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Base Sequence
- Colorectal Neoplasms
- DNA, Satellite
- Female
- Fluorescence
- Gene Deletion
- Genes, APC
- Genes, DCC
- Genes, MCC
- Genes, Neurofibromatosis 1
- Genes, Retinoblastoma
- Genes, Tumor Suppressor
- Genes, Wilms Tumor