Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Applying microsatellite multiplex PCR analysis (MMPA) for determining allele copy-number status and percentage of normal cells within tumors.

PloS one - 1 Jan 2012

Garcia-Linares Carles, Mercadé Jaume, Gel Bernat, Biayna Josep, Terribas Ernest, Lázaro Conxi, Serra Eduard

Abstract excerpt

The study of somatic genetic alterations in tumors contributes to the understanding and management of cancer. Genetic alterations, such us copy number or copy neutral changes, generate allelic imbalances (AIs) that can be determined using polymorphic markers. Here we report the development of a simple set of calculations for analyzing microsatellite multiplex PCR data from control-tumor pairs that allows us to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microsatellite Repeats

Share to Multiplex Polymerase Chain Reaction

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22916147
DOI: 10.1371/journal.pone.0042682
PMCID: PMC3419736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Applying microsatellite multiplex PCR analysis (MMPA) for determining allele copy-number status and percentage of normal cells within tumors.PMID 22916147Read ↗

High-Resolution DNA Copy Number Profiling of Malignant Peripheral Nerve Sheath Tumors Using Targeted Microarray-Based Comparative Genomic HybridizationSemantic proximity Read ↗

Classifying Melanocytic Tumors Based on DNA Copy Number ChangesSemantic proximity Read ↗

Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotypeSemantic proximity Read ↗

Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden.Semantic proximity Read ↗

Droplet Digital PCR for Fast and Accurate Characterization of NF1 Locus Deletions: Confirmation of the Predominant Maternal Origin of Type-1 Deletions.Semantic proximity Read ↗

Detection of DNA copy number alterations by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of single nucleotide polymorphisms.Semantic proximity Read ↗

Assessment of the frequency of allelic imbalance in human tissue using a multiplex polymerase chain reaction system.Semantic proximity Read ↗

Dissecting loss of heterozygosity (LOH) in neurofibromatosis type 1-associated neurofibromas: Importance of copy neutral LOHSemantic proximity Read ↗

Microsatellite instability and its relevance to cutaneous tumorigenesis.Semantic proximity Read ↗

Interpreting aCGH-defined karyotypic changes in gliomas using copy number status, loss of heterozygosity and allelic ratios.Semantic proximity Read ↗

Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas.Semantic proximity Read ↗

Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.