Article
Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2004
Ramburan Amsha, Chetty Runjan, Hadley G P, Naidoo Richard, Govender Dhirendra
Abstract excerpt
Microsatellite instability has been reported in a wide variety of cancer types. Inactivation or loss of tumour suppressor genes has been shown to result in cell cycle deregulation and neoplastic growth. We conducted a microsatellite study using fluorescent-based DNA technology to determine whether mutations in the microsatellite sequences of the deleted in colorectal cancer (DCC) gene, a tumour suppressor at...
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