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Article

NF1 gene loss of heterozygosity and expression analysis in sporadic colon cancer

20 Apr 2005

Abstract excerpt

BACKGROUND AND AIMS: Colon cancer tumorigenesis is a multistep process of mutation accumulation in a number of oncogenes and tumour suppressor genes. NF1 gene protein, neurofibromin, acts as a tumour suppressor by turning the active form of Ras into an inactive form. This molecular switch has an important role in the control of the cell cycle and differentiation, and changes in Ras activity are present in many...

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PMID: 15840687
DOI: 10.1136/gut.2004.053348

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