Article
T-cell malignancies with mature phenotypes: altered cell cycle regulation by HLA class I molecules.
Blood - 15 Oct 1991
Turco M C, Alfinito F, De Felice M, Lamberti A, Ferrone S, Venuta S
Abstract excerpt
Soluble anti-HLA class I monoclonal antibodies (MoAbs) modulate normal T-lymphocyte proliferation induced via the CD3/Ti and the CD2 pathway, but do not induce proliferation of normal T lymphocytes in the absence of additional mitogenic stimuli. In this report, we show that anti-HLA class I MoAbs...
Topics
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- CD2 Antigens
- CD3 Complex
- Cell Division
- Gene Expression
- Histocompatibility Antigens Class I
- Humans
- Leukemia, Prolymphocytic
- Leukemia, T-Cell
- Mitogens
- Phenotype
- Protein Kinase C
- Receptors, Antigen, T-Cell
- Receptors, Immunologic
- Tumor Cells, Cultured