Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic correction of cultured T cells from an adenosine deaminase-deficient patient: characteristics of non-transduced and transduced T cells.

European journal of immunology - 1 Jan 1992

Braakman E, Van Beusechem V W, Van Krimpen B A, Fischer A, Bolhuis R L, Valerio D

Abstract excerpt

T lymphocytes derived from peripheral blood of a patient with adenosine deaminase (ADA) deficiency were expanded in vitro. The human ADA (hADA) gene was introduced into these replicating ADA- T cells with the use of an amphotropic recombinant retrovirus carrying the hADA gene. Subsequently, infected T cells were selected on the basis of their ADA expression, by exposure to a combination of the toxic agent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4 Antigens
Share to CD8 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Genetic Therapy

Share to Infant

Share to Phenotype

Share to T-Lymphocytes

Share to Transduction, Genetic

Source

Identifiers

PMID: 1730260
DOI: 10.1002/eji.1830220111

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic correction of cultured T cells from an adenosine deaminase-deficient patient: characteristics of non-transduced and transduced T cells.PMID 1730260Read ↗

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA <sup>−</sup> Immunodeficient PatientsSemantic proximity Read ↗

An in Vivo Model of Somatic Cell Gene Therapy for Human Severe Combined ImmunodeficiencySemantic proximity Read ↗

T-cell lines from 2 patients with adenosine deaminase (ADA) deficiency showed the restoration of ADA activity resulted from the reversion of an inherited mutation.Semantic proximity Read ↗

Treatment of Severe Combined Immunodeficiency Disease (SCID) due to Adenosine Deaminase Deficiency with CD34 <sup>+</sup> Selected Autologous Peripheral Blood Cells Transduced with a Human ADA Gene (Amendment). National Institutes of HealthSemantic proximity Read ↗

T Lymphocyte-Directed Gene Therapy for ADA <sup>−</sup> SCID: Initial Trial Results After 4 YearsSemantic proximity Read ↗

In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes.Semantic proximity Read ↗

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell ClonesSemantic proximity Read ↗

Therapy with cultured T cells: principles revisitedSemantic proximity Read ↗

Retrovirus-mediated gene transfer into CD4+ and CD8+ human T cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells.Semantic proximity Read ↗

Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.Semantic proximity Read ↗

Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency.Semantic proximity Read ↗

Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.