Article
Protein interactions at Sp1-like sites in the TGF alpha promoter as visualized by in vivo genomic footprinting.
Oncogene - 1 Nov 1994
Chen X, Wright K L, Berkowitz E A, Azizkhan J C, Ting J P, Lee D C
Abstract excerpt
Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor Sp1 in active expression from the promoter, particularly from the -58 site (Chen et al., 1992; Shin et al., 1992). In the present report we have examined the...
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