Article
Protein interactions at Sp1-like sites in the TGF alpha promoter as visualized by in vivo genomic footprinting.
Oncogene - 1 Nov 1994
Chen X, Wright K L, Berkowitz E A, Azizkhan J C, Ting J P, Lee D C
Abstract excerpt
Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor Sp1 in active expression from the promoter, pa...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Rats
- Sp1 Transcription Factor
- Transcription, Genetic
- Transforming Growth Factor alpha