Article
Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter.
The Journal of biological chemistry - 5 Oct 1992
O'Reilly M A, Geiser A G, Kim S J, Bruggeman L A, Luu A X, Roberts A B, Sporn M B
Abstract excerpt
Transforming growth factor TGF-beta 2 is encoded by multiple mRNA transcripts of 5.8, 5.1, 4.0, 3.8, and 2.8 kilobase pairs (kb) that are expressed in various human and monkey cells. Northern blot analysis using genomic fragments of DNA was used to demonstrate that some of this size heterogeneity is due to differences in the length of the 5'-untranslated region. Probes that were colinear with the first 600...
Topics
- Activating Transcription Factors
- Binding Sites
- Blood Proteins
- Blotting, Northern
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Cyclic AMP Response Element-Binding Protein
- DNA
- DNA Probes
- Enhancer Elements, Genetic