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Article

A novel SP-1 site in the human interleukin-1 beta promoter confers preferential transcriptional activity in keratinocytes.

European journal of immunology - 1 Dec 1996

Husmann M, Jehnichen P, Jahn B, Schlosshan D, Romahn E, Marx J

Abstract excerpt

To investigate the mechanisms of transcriptional activation of interleukin-1beta (IL-1beta) in non-monocytic cells, we constructed a series of reporter plasmids with the bacterial chloramphenicol acetyltransferase gene linked to various parts of the human IL-1beta promoter and performed transient...

Topics

Cell Line, Transformed
Cell Nucleus
Genes, Reporter
Humans
Interleukin-1
Keratinocytes
Monocytes
Mutation
Promoter Regions, Genetic
Sp1 Transcription Factor
Transcription, Genetic
Transcriptional Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 8977297
DOI: 10.1002/eji.1830261228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8977297-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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