Article
Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif.
Nucleic acids research - 11 Dec 1991
Lafyatis R, Denhez F, Williams T, Sporn M, Roberts A
Abstract excerpt
We have previously characterized the TGF-beta 3 promoter and shown that the activity of this promoter is highly variable in different cell types. Although the promoter contains a proximal cAMP responsive element, which is critical to basal and forskolin-induced promoter activity, this element is not responsible for the variable, cell-specific regulation of the promoter. In this paper, we identify a 25 base pair...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Molecular Sequence Data
- Mutation