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Article

Transcription factor AP2 is required for expression of the rat transforming growth factor-alpha gene.

Oncogene - 8 May 1997

Berkowitz E A, Hecht C P, Azizkhan J C, Chen X, Lee D C

Abstract excerpt

DNase I footprinting of the rat TGF alpha promoter in the presence of crude cell nuclear extract revealed three sites of protein-DNA interaction (Fp-A, Fp-B, Fp-C) in the region from -222 to +73. Mutation of specific sites within the Fp-A and Fp-B regions reduced expression of a TGF alpha promoter-reporter gene (TGF alphaLUC) from 50-90% in transiently transfected CHO cells, indicating the importance of...

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Source

Identifiers

PMID: 9174059
DOI: 10.1038/sj.onc.1201051

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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