Article
Transcription factor AP2 is required for expression of the rat transforming growth factor-alpha gene.
Oncogene - 8 May 1997
Berkowitz E A, Hecht C P, Azizkhan J C, Chen X, Lee D C
Abstract excerpt
DNase I footprinting of the rat TGF alpha promoter in the presence of crude cell nuclear extract revealed three sites of protein-DNA interaction (Fp-A, Fp-B, Fp-C) in the region from -222 to +73. Mutation of specific sites within the Fp-A and Fp-B regions reduced expression of a TGF alpha promote...
Topics
- Animals
- Base Sequence
- Binding Sites
- CHO Cells
- Cell Line
- Cell Line, Transformed
- Cricetinae
- DNA Footprinting
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Electrophoresis
- Epithelial Cells
- Gene Expression Regulation
- Liver
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic