Article
The binding of transcription factor Sp1 to multiple sites is required for maximal expression from the rat transforming growth factor alpha promoter.
Oncogene - 1 Sept 1992
Chen X, Azizkhan J C, Lee D C
Abstract excerpt
Transcription from the rat transforming growth factor alpha (TGF-alpha) promoter initiates at multiple sites within a 200-bp G+C-rich region that lacks TATA and CAAT motifs but contains multiple potential binding sites for the transcription factor Sp1. In the present study, we used deletion analy...
Topics
- Animals
- Base Sequence
- Binding Sites
- CHO Cells
- Chloramphenicol O-Acetyltransferase
- Cricetinae
- Drosophila
- Gene Expression
- HeLa Cells
- Humans
- Methylation
- Molecular Sequence Data