Article

Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression

2026-07-15

Abstract excerpt

RARg is expressed during embryogenesis by stem/primitive progenitor cells indicating a role in controlling their development. Support to this view is that a physiological level of 10 nM of the RARg agonist AGN205327 blocked stem/progenitor cell differentiation during zebrafish embryo-genesis, mouse gastruloid development, and adult chondro- and osteogenesis. Similarly, transgene expression of RARg or the use of th...

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Literature Corpus work: b31620a1-925a-5806-a595-716b3b2b2f6c
DOI: 10.20944/preprints202607.1104.v1

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