Article
Retinoic acid fails to induce expression of Hox genes in differentiation-defective murine embryonal carcinoma cells carrying a mutant gene for alpha retinoic acid receptor.
Differentiation; research in biological diversity - 1 Jun 1993
Pratt M A, Langston A W, Gudas L J, McBurney M W
Abstract excerpt
Murine P19 embryonal carcinoma cells irreversibly differentiate into neuroectoderm following brief exposure to retinoic acid (RA). We compared the expression of RA-responsive genes in P19 cells and in a mutant cell line from mouse, RAC65, which fails to differentiate in RA. Some RA-responsive genes were normally regulated by RA in RAC65 cells while others were not. Amongst the latter were Oct-3 and PEA-3, whose...
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