Article
Retinoic acid fails to induce expression of Hox genes in differentiation-defective murine embryonal carcinoma cells carrying a mutant gene for alpha retinoic acid receptor.
Differentiation; research in biological diversity - 1 Jun 1993
Pratt M A, Langston A W, Gudas L J, McBurney M W
Abstract excerpt
Murine P19 embryonal carcinoma cells irreversibly differentiate into neuroectoderm following brief exposure to retinoic acid (RA). We compared the expression of RA-responsive genes in P19 cells and in a mutant cell line from mouse, RAC65, which fails to differentiate in RA. Some RA-responsive gen...
Topics
- Animals
- Carrier Proteins
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genes, Homeobox
- Mice
- Mutation
- Neoplasm Proteins
- Octamer Transcription Factor-3
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Receptors, Retinoic Acid
- Teratoma