Article
Tissue-specific distribution of a novel C-terminal truncation retinoic acid receptor mutant which acts as a negative repressor in a promoter- and cell-type-specific manner.
Molecular and cellular biology - 1 Apr 1995
Matsui T, Sashihara S
Abstract excerpt
A cDNA clone which encodes a truncation form of the gamma subtype of the retinoic acid receptor (RAR gamma) has been isolated. The mutant RAR gamma (RAR gamma Bm382) has lost its 65 C-terminal amino acids, thus truncating a part of the dimerization and activation domains. By using a reverse trans...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA, Complementary
- HeLa Cells
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Protein Binding
- Receptors, Retinoic Acid
- Repressor Proteins
- Sequence Deletion
- Structure-Activity Relationship
- Tissue Distribution