A Mouse-Adapted Enterovirus 71 Strain Causes Neurological Disease in Mice after Oral Infection

Abstract excerpt

A mouse-adapted enterovirus 71 (EV71) strain with increased virulence in mice, MP4, was generated after four serial passages of the parental EV71 strain 4643 in mice. Strain MP4 exhibited a larger plaque size, grew more rapidly, and was more cytotoxic in vitro than strain 4643. Although strains 4643 and MP4 both induced apoptosis of SK-N-SH human neuroblastoma cells, MP4 was more virulent than 4643 in 1-day-old...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA regulation and disease
• Share to Viral gastroenteritis research and epidemiology
• Share to Viral Infections and Immunology Research