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Article

Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction.

Journal of medicinal chemistry - 16 Sept 1994

Cushman M, Golebiewski W M, McMahon J B, Buckheit R W, Clanton D J, Weislow O, Haugwitz R D, Bader J P, Graham L, Rice W G

Abstract excerpt

Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was synthesized from commercially available starting materials by a convergent route. Cosalane proved to be a potent inhibitor of HIV with a broad range of activity against a...

Topics

Antiviral Agents
Aurintricarboxylic Acid
B-Lymphocytes
Cell Fusion
Cells, Cultured
DNA, Viral
HIV Infections
HIV-1
HeLa Cells
Humans
Macrophages
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Virion

Virus Replication

Zidovudine

Source

Identifiers

PMID: 7932526
DOI: 10.1021/jm00045a008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7932526-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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