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Article

Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy.

The Journal of clinical investigation - 1 Jan 2005

Hauber Ilona, Bevec Dorian, Heukeshoven Jochen, Krätzer Friedrich, Horn Florian, Choidas Axel, Harrer Thomas, Hauber Joachim

Abstract excerpt

The introduction of highly active antiretroviral therapy (HAART) has significantly decreased morbidity and mortality among patients infected with HIV-1. However, HIV-1 can acquire resistance against all currently available antiretroviral drugs targeting viral reverse transcriptase, protease, and gp41. Moreover, in a growing number of patients, the development of multidrug-resistant viruses compromises HAART...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15630446
DOI: 10.1172/JCI21949
PMCID: PMC539192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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