Article
Antiviral activity of CYC202 in HIV-1-infected cells.
The Journal of biological chemistry - 28 Jan 2005
Agbottah Emmanuel, de La Fuente Cynthia, Nekhai Sergie, Barnett Anna, Gianella-Borradori Athos, Pumfery Anne, Kashanchi Fatah
Abstract excerpt
There are currently 40 million individuals in the world infected with human immunodeficiency virus (HIV). The introduction of highly active antiretroviral therapy (HAART) has led to a significant reduction in AIDS-related morbidity and mortality. Unfortunately, up to 25% of patients discontinue their initial HAART regimen. Current HIV-1 inhibitors target the fusion of the virus to the cell and two viral proteins,...
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