Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells

1 Nov 2016

Abstract excerpt

ABSTRACT GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV expressionex vivoin latently infected peripheral blood mononuclear cells (PBMCs) from virally suppressed patients. Currently, GS-9620 is under clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to Immune Response and Inflammation
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27799218
DOI: 10.1128/aac.01369-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear CellsPMID 27799218Read ↗

Safety, pharmacokinetics and pharmacodynamics of the oral toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C.Semantic proximity Read ↗

Molecular Determinants of GS-9620-Dependent TLR7 Activation.Semantic proximity Read ↗

TLR Agonists Enhance HIV-Specific T-Cell Response Mediated by Plasmacytoid Dendritic Cells in Diverse HIV-1 Disease Progression PhenotypesSemantic proximity Read ↗

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Toll-like receptor agonists enhance HIV-specific T cell response mediated by plasmacytoid dendritic cells in diverse HIV-1 disease progression phenotypes.Semantic proximity Read ↗

Interferons and HIV Infection: The Good, the Bad, and the UglySemantic proximity Read ↗

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infectionSemantic proximity Read ↗

Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580Semantic proximity Read ↗

WY14643 Increases Herpesvirus Replication Independently of PPARα Expression and Inhibits IFNβ ProductionSemantic proximity Read ↗

Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gammaas an intrinsic negative regulator of viral replicationSemantic proximity Read ↗

Production of Interferon α by Human Immunodeficiency Virus Type 1 in Human Plasmacytoid Dendritic Cells Is Dependent on Induction of AutophagySemantic proximity Read ↗

The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4 <sup>+</sup> T cell depletion, viral load and total HIV-1 DNA in HIV-1 infected humanized miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.