Article
PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003
Li F, Goila-Gaur R, Salzwedel K, Kilgore N R, Reddick M, Matallana C, Castillo A, Zoumplis D, Martin D E, Orenstein J M, Allaway G P, Freed E O, Wild C T
Abstract excerpt
New HIV therapies are urgently needed to address the growing problem of drug resistance. In this article, we characterize the anti-HIV drug candidate 3-O-(3',3'-dimethylsuccinyl) betulinic acid (PA-457). We show that PA-457 potently inhibits replication of both WT and drug-resistant HIV-1 isolates and demonstrate that the compound acts by disrupting a late step in Gag processing involving conversion of the capsid...
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